News & Publications

June 16, 2015 In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

BACKGROUND & AIMS: We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) as well as human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied to study the epithelial response to infection with Helicobacter pylori. … Continue reading In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection

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June 15, 2015 Prospective derivation of a living organoid biobank

3D organoid cultures derived from healthy and tumor tissue from colorectal cancer patients are used for a high throughput drug screen to identify genedrug associations that may facilitate personalized therapy. Read more here    

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November 7, 2014 Stem cell research Hans Clevers nominated ‘NATIONAL ICON 2014’

Utrecht, November 7, 2014 – Yesterday, during a ceremony attended by His Majesty the King, Dutch Minister of Economic Affairs Henk Kamp announced that Hans Clevers, founding director of foundation Hubrecht Organoid Technology (HUB), was nominated “National Icon 2014”. Projects with a potential to make significant contributions to solving global societal challenges qualify to become … Continue reading Stem cell research Hans Clevers nominated ‘NATIONAL ICON 2014’

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October 14, 2014 Successfully grow breast cancer mini-organs “organoids” from cancer tissue

The HUB Foundation and Boehringer Ingelheim successfully grow breast cancer mini-organs “organoids” from cancer tissue Living Biobank of breast cancer organoids aims at improving discovery of innovative drugs for personalized medicine Utrecht, October 14, 2014 – The HUB Foundation for Organoid Technology and Boehringer Ingelheim announced today the successful completion of the first phase of … Continue reading Successfully grow breast cancer mini-organs “organoids” from cancer tissue

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September 25, 2014 Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 Sep 25;159(1):163-75. doi: 10.1016/j.cell.2014.08.017. Epub 2014 Sep 4.   Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RG, Cuppen E, Chen Y, Sawyers CL, Clevers HC   Abstract … Continue reading Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

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January 21, 2014 Agreement on the manufacturing of cell culture media for organoids

The HUB Foundation for Organoid Technology and STEMCELL Technologies Sign Agreement on the Manufacturing of Cell Culture Media for Organoids. Agreement supports further development of organoids as next-generation drug screening platform Utrecht, January 21, 2014 – The HUB Foundation for Organoid Technology announced today that it has signed a licensing agreement with STEMCELL Technologies Inc. … Continue reading Agreement on the manufacturing of cell culture media for organoids

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December 18, 2013 Generating a living biobank for breast cancer

The HUB Foundation for Organoid Technology and Boehringer Ingelheim Sign Agreement on Generating a Living Biobank for Breast Cancer. – Organoids represent an exciting new tool for developing precision cancer drugs Utrecht, December 18, 2013 – The HUB Foundation for Organoid Technology announced today that it has signed an agreement with Boehringer Ingelheim to generate … Continue reading Generating a living biobank for breast cancer

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February 14, 2013 In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013 Feb 14;494(7436):247-50. doi: 10.1038/nature11826. Epub 2013 Jan 27.   Huch M1, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H. … Continue reading In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

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November 4, 2011 Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium.

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011 Nov;141(5):1762-72. doi: 10.1053/j.gastro.2011.07.050. Epub 2011 Sep 2.   Sato T1, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H.   Abstract BACKGROUND & AIMS: … Continue reading Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium.

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January 20, 2011 Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28. Sato T1, van wholesale nfl jerseys Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker cancer. N, Shroyer NF, van de Lgr5 Wetering M, Clevers H.   Abstract Homeostasis … Continue reading Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

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