News & Publications

May 6, 2017 Organoids are a finalist for the European Inventor Award 2017!

Once again this year, the European Patents Office (EPO) is holding a vote to decide the attribution of the European Inventor Award. Launched by the EPO in 2006 and considered one of the most prestigious awards of its kind, it gives inventors recognition for their work, while paying tribute to their creativity and use of … Continue reading Organoids are a finalist for the European Inventor Award 2017!

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February 21, 2017 The HUB has a Cystic Fibrosis FIS assay article published in JoVE!

We are happy to announce that our article “Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients” has been published in the Journal of Visualized Experiments. Interested? Just follow the link! http://www.jove.com/video/55159/forskolin-induced-swelling-intestinal-organoids-an-vitro-assay-for

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January 5, 2017 HUB and Dutch health insurance companies to validate use of organoids for Cystic Fybrosis

Utrecht, 4 January 2017 – Hubrecht Organoid Technology (HUB), and the health insurance companies CZ, Zilveren Kruis  and Menzis announced today that they will start a €3 million validation trial for use of HUB Organoid Technology to test if it can be used to determine the response of Cystic Fibrosis (CF) patients to new drug … Continue reading HUB and Dutch health insurance companies to validate use of organoids for Cystic Fybrosis

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December 18, 2016 3D cancer cells library

A global effort to create a library of human cancer models using next-generation cell culture techniques launched last summer. The Human Cancer Models Initiative’s founding members include the Hubrecht Organoid Technology Foundation in Utrecht, the Netherlands; Cancer Research UK, in London; the National Cancer Institute (NCI) in Bethesda, Maryland; and the Wellcome Trust Sanger Institute … Continue reading 3D cancer cells library

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October 9, 2016 Cystic fibrosis patients benefit from mini guts

A new test with ‘mini-guts’ or organoids can inform Cystic Fibrosis (CF) patients and their physicians whether they can benefit from a novel treatment against the disease. A major problem in the treatment of CF is the enormous genetic variability among patients. This means that for up to 50% of them it is unclear if … Continue reading Cystic fibrosis patients benefit from mini guts

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July 12, 2016 International collaboration to create new cancer models to accelerate research

An international project to develop a large, globally accessible, bank of new cancer cell culture models for the research community launches today (Monday). The National Cancer Institute (NCI), Cancer Research UK, the Wellcome Trust Sanger Institute and the foundation Hubrecht Organoid Technology are joining forces to develop the Human Cancer Models Initiative (HCMI) which will … Continue reading International collaboration to create new cancer models to accelerate research

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August 6, 2015 Galapagos licenses Organoid Technology from the HUB foundation for use in cystic fibrosis and IBD research

Galapagos NV (Euronext & NASDAQ: GLPG) announced on July 14th 2015 that it has entered into a licensing agreement with the HUB foundation for use of Organoid Technology for pre-clinical research in cystic fibrosis (CF) and inflammatory bowel disease (IBD). Read more

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June 16, 2015 Organoid models of human and mouse ductal pancreatic cancer

Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tissues. Pancreatic organoids can be rapidly generated from resected tumors … Continue reading Organoid models of human and mouse ductal pancreatic cancer

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Long-term culture of genome-stable bipotent stem cells from adult human live

Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or function in vitro. We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be differentiated into functional hepatocytes in vitro and in vivo. … Continue reading Long-term culture of genome-stable bipotent stem cells from adult human live

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