Hubrecht Organoid Technology (The HUB) is a not-for-profit organization founded by the Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands.
The HUB is founded on the pioneering work of Prof. Dr. Hans Clevers who discovered methods to grow stem cell-derived human epithelial ‘mini-organs’ (organoids) from tissues of patients with various diseases including cancer and cystic fibrosis.
In cell culture, organoids stably maintain the genotype/phenotype of the patient’s diseased tissue, thereby representing an in vitro platform for preclinical drug discovery and validation and a tool for precision medicine.
The HUB has established a ‘Living Biobank’, a rapidly-growing collection of well-characterized organoids derived from patient tissues. Through a combination of the proprietary Organoid Technology and the ‘Living Biobank’, the HUB provides access to a unique and robust platform that links patient-specific genetic and phenotypic information to preclinical and clinical drug-responsiveness.